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в ответ MolMed 23.09.21 14:14
Nature - Rapid and stable mobilization of CD8+ T cells by SARS-CoV-2 mRNA vaccine
Here we show on a single-epitope level that a stable and fully functional CD8+ T cell response is vigorously mobilized one week after prime vaccination with bnt162b2, when circulating CD4+
T cells and neutralizing antibodies are still weakly detectable. Boost
vaccination induced a robust expansion that generated highly
differentiated effector CD8+ T cells; however, neither the
functional capacity nor the memory precursor T cell pool was affected.
Compared with natural infection, vaccine-induced early memory T cells
exhibited similar functional capacities but a different subset
distribution.
