получается, что адъювант Нововакса это в основном QS-7 + немного QS-21.

...Quil A was further purified into three purified saponin fractions, fraction A (QS-7), fraction B (QS-17 and QS-18) and fraction C (QS-21). These fractions have been characterized for their immune stimulating properties, toxicity and hemolytic activity [56,57]. Fraction B had the highest immune stimulating properties, but was highly toxic and is therefore not suitable for any clinical application. Fraction C has also high immune stimulating properties enhancing both cellular and humoral immune responses, but displayed mild toxicity and hemolytic activity while fraction A has moderate immune stimulating properties mainly promoting cellular immune responses and is virtually non-toxic or hemolytic.

For the ISCOM-based adjuvant Matrix-M (Novavax) also fraction A and fraction C were used as saponin source. Interestingly, by physically separate the A and C fractions into two separate particles (Matrix-A and Matrix-C), the toxicity was reduced as assessed by toxicity studies in animal models as compared to particles that contain both saponin fractions in a single particle. These results led to the final formulation of Matrix-M that contains the two individual Matrix-A (85-92%) and Matrix-C (8-15%) particles co-formulated with free antigen [50,62].

Про QS-7 пишут, что он "significantly less toxic than QS-21."