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нп
COVID-19 is a spectrum of clinical symptoms in humans caused by
infection with SARS-CoV-2, a recently emerged coronavirus that has
rapidly caused a pandemic. Coalescence of a second wave of this virus
with seasonal respiratory viruses, particularly influenza virus is a
possible global health concern. To investigate this, transgenic mice
expressing the human ACE2 receptor driven by the epithelial cell
cytokeratin-18 gene promoter (K18-hACE2) were first infected with IAV
followed by SARS-CoV-2. The host response and effect on virus biology
was compared to K18-hACE2 mice infected with IAV or SARS-CoV-2 only.
Infection of mice with each individual virus resulted in a disease
phenotype compared to control mice. Although, SARS-CoV-2 RNA synthesis
appeared significantly reduced in the sequentially infected mice, these
mice had a more rapid weight loss, more severe lung damage and a
prolongation of the innate response compared to singly infected or
control mice. The sequential infection also exacerbated the
extrapulmonary manifestations associated with SARS-CoV-2. This included a
more severe encephalitis. Taken together, the data suggest that the
concept of “twinfection” is deleterious and mitigation steps should be
instituted as part of a comprehensive public health response to the
COVID-19 pandemic.
После гриппа лучше короной не заражаться. https://www.biorxiv.org/content/10.1101/2020.10.13.334532v...