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Витамин Д регулирует проницаемость стенок кишечника: https://www.mdpi.com/2072-6643/13/3/1011/htm
Decreased serum vitamin D (VD) levels have been associated with
gastrointestinal (GI) disorders, including irritable bowel syndrome
(IBS). VD can also modulate the intestinal barrier. Given the link
between the GI barrier’s alterations and diet, attention has aroused the
positive effects of the Low FODMAP Diet (LFD) on IBS patients’ symptom
profile. We evaluated the GI symptoms and the urinary and circulating
markers of GI barrier function, the markers of inflammation and
intestinal dysbiosis in 36 IBS patients with predominant diarrhea
(IBS-D) (5 men and 31 women, 43.1 ± 1.7 years) categorized for their
circulating VD levels in low (L-VD) and normal (N-VD) (cutoff = 20
ng/mL). Evaluations were performed before and after 12 weeks of LFD. At
the baseline, L-VD patients showed a significantly worse symptom profile
and altered small intestinal permeability (s-IP) than N-VD. After LFD, a
significant increase in the circulating VD levels in both the subgroups
and a significant improvement of s-IP in L-VD patients occurred.
Finally, VD levels negatively correlated with the symptom score and
fecal zonulin. These data highlight the close relationship between VD
and the intestinal barrier and support their involvement in IBS-D
pathophysiology. Moreover, the potentially positive role of LFD in the
management of IBS-D was confirmed.
